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GTFs are also intimately involved in the process of gene regulation, and most are required for life. ![]() GTFs, RNA polymerase, and the mediator (a multi-protein complex) constitute the basic transcriptional apparatus that first bind to the promoter, then start transcription. ![]() General transcription factors ( GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites ( promoter) on DNA to activate transcription of genetic information from DNA to messenger RNA. ![]() In the middle part above the promoter, the pink color part of the transcription factors are the General Transcription Factors. |
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